
High Throughput Genome Engineering (HTGE)→
Karolinska Institutet
Biomedicum 9B, B0951,
Solnavägen 9,
171 65 Solna,
Sweden
bernhard.schmierer@ki.se
Diseases studied: Cancer, neurological disorders, infection
Model systems used: Cell lines, primary cells, organoids
Instruments of interest: FACS, ddPCR, X10 Chromium, NovaSeq
Established techniques: CRISPR-knock-out screening, CRISPR-inhibition, CRISPR-activation, precision editing in cell lines, drug-target interaction by CRISPR functional genomics, drug-target mechanism of action studies by CRISPR, pooled C RISPR-perturbation followed single-cell RNASeq