Chemical Proteomics & Proteogenomics→
Karolinska Institutet & SciLifeLab,
Tomtebodavägen 23A,
171 65 Solna,
Sweden
rozbeh.jafari@ki.se
massimiliano.gaetani@ki.se
Diseases studied: Cancer, disease models including the study of treatment compound(s)
Model systems used: Clinical samples, Cell Lines
Instruments of interest: Mass Spectrometry and proteomics
Established techniques: Proteome Integral Solubility Alteration (PISA) assay; Functional Identification of Target by Expression Proteomics (FITExP); Thermal Proteome Profiling (TPP); ProTargetMiner (proteome signature library of anticancer molecules); RedOx Proteomics; Identification of enzyme substrates by PISA; Hydrogen Deuterium Exchange Mass Spectrometry (HDX-MS) for binding site determination, epitope mapping and conformational changes